 45-year-old homeless-addicted male with second flare of psoriatic erythroderma and positive PCR test for COVID-19, whose first attack occurred two months earlier when he was screened for SARS-CoV-2 before admission and discharged after being treated with cyclosporine, experienced a flare due to both factors. This article was authored by Faribah Ghulamkarpur, Mohamed Reza Pohani, Fahime Abdullah Himmichd and others.