 Abstract Alzheimer's disease, AD, is a common neurodegenerative disorder affecting millions worldwide. Women are more likely to develop AD than men, leading researchers to investigate potential gender-based differences in the disease. This study examined the effects of AD on the brains of both male and female patients using various imaging techniques, as well as analyzed their blood samples for biomarkers. The results showed that women had greater brain metabolic impairment compared to men, and that this impairment correlated with the progression of the disease. Additionally, the study identified a set of genes that were differentially expressed between males and females, which could be used to identify AD-positive individuals. These findings suggest that understanding the unique characteristics of AD in women may lead to improved diagnosis and treatment options. This article was authored by Zhong Chen Park, Han Biolim, Minitsa Byun, and others.