 Hydrogen bonds are essential for creating order in biological systems, allowing for the formation of crystal structures which can have unique physical properties. These properties can be manipulated through the control of hydrogen-bonding interactions between amino and carboxylic acid groups. By varying the strength of these interactions, different physical properties such as thermal, mechanical, electronic, and piezoelectric responses can be achieved. Specifically, the weak interaction between oxygen and hydrogen atoms leads to low mechanical strength, allowing for ion displacement upon stress, resulting in a strong piezoelectric response. This study provides insight into how hydrogen bonding can be used to manipulate the physical properties of biological crystals, providing a basis for the development of novel materials for energy harvesting applications. This article was authored by Hu Yuan, Ben Shui, Ding Yang, and others.