 Magnetite nanoparticles, Fe3O4, are promising materials in medical applications and can be incorporated into mesoporous materials to increase drug loading, while reducing magnetization saturation. Direct synthesis of mesoporous structures using a one-pot coprecipitation reaction at room temperature with different bases, such as NaOH, KOH or C2H5, for NOH is possible. Magnetite shows superparamagnetism at room temperature and a saturation magnetization value dependent on crystal size, and nanoparticle agglomeration, which forms mesoporous structures affected by pH, alkali nature, addition rate, and drying modality of synthesized powders. This article was authored by Maria Cristina Mascallo, Yongbing Pei, and Terry A. Ring.