 Biosensors have acquired paramount importance in the field of drug discovery, biomedicine, food safety standards, defense, security and environmental monitoring. Use of aptomers or nucleotides, affobodies, peptide arrays and molecule-imprinted polymers provide tools to develop innovative biosensors over classical methods. This article was authored by Vinesh Bariyas, Sudakumari Isisi, Bala Subramani on ESN-THL, KU Amaran, and others.