 This research paper examines the potential combination therapy for colorectal cancer treatment. The authors identified a novel mechanism whereby two drugs, topoisomerase I inhibitor and NED-8 activator, worked together to kill cancer cells. They found that when these two drugs were combined, they had a synergistic effect, resulting in greater cell death than either drug alone. This combination therapy was tested in both laboratory experiments and clinical trials, and showed promising results. This article was authored by Hilaun Sun, Simone Beachler, Xiaovijong, and others.