 The increasing prevalence of kidney disease has led to a greater need for effective treatments. Gene and cell-based approaches are being explored as potential solutions, but their success depends on the ability to deliver them to the kidney. This review summarizes recent advances in this area, including the use of recombinant proteins, gene, cell, organoids, and RNA interference, RNA, technology, which have shown promise in experimental models. Research into supporting mechanisms, such as improving delivery methods, is also discussed. These developments could lead to more effective treatments for acute and chronic kidney disease. This article was authored by Peter R. Coridan, Peter R. Coridan and Peter R. Coridan.