 So if we now apply this to a real protein, let's show you one, what happens when a protein inserts depending both on the protein and the lipid environment, we might have this, you could imagine that the lipid is a relatively rigid environment and in that case we would have this scenario that the protein would adapt to fit the bilayer. Do you see here how all those helices are tilting a bit? In fact, tilting helices is great for packing helices. That has to do with the way the side chains are organized in an alpha helix. If you put them in a parallel fashion, side chains would in general bump into each other, but if they're slightly tilted, the ridges of one helix will fit into the grooves of another helix. And here the lipid environment might actually help that. The other alternative is that the protein is quite rigid. If the protein is quite rigid, we would rather end up on the right where we have the lipids, the membrane will adapt to fit the protein. It turns out that if we now have the protein undergo a conformational transition, for instance with changing pH, changing pressure or something, this way we could actually either have the cell influence say a protein to open a channel or something, or a protein influence a membrane say start to bend the membrane, which is how we achieve a whole lot of functionality in the cell. So in general, these properties are true. The only question is how Anthony, Kylian and others were able to study them.