 The study aimed to identify factors associated with COVID-19 vaccine hesitancy among Canadians prior to the regulatory approval of the vaccines, finding that younger age, lower education, and non-liberal political leaning were significantly associated with vaccine hesitancy. Messaging related to preventing COVID among friends and family, highlighting the benefits, emphasizing safety and efficacy of COVID-19 vaccination, and ensuring that healthcare workers are knowledgeable and supported in their vaccination counseling may be effective for vaccine-hesitant populations. This article was authored by Jamie L. Benham, Omid Atabadi, Robert J. Oxaby, and others.