 The study evaluated the effectiveness of a web-based, individually customizable intervention called CHICOS for increasing HPV vaccine utilization among Latinos in family medicine practices. However, the results showed that there were no significant differences between the CHICOS and untalered arms in any vaccination measure, or between the untalered or CHICOS arms and usual care. The study suggests that a tailored educational intervention may not be effective for increasing HPV vaccine uptake among Latino adolescents or young adults, but the higher than expected baseline levels of positive vaccination attitudes could have diminished the statistical power of the study. This article was authored by Amanda F. Dempsey, Julie Metins, Carter Sevik, and others.