 Silver nanoparticles, AGNPS, are increasingly being used in a variety of applications due to their unique physical and chemical properties. These particles have been shown to be highly toxic to cells, leading to potential health risks if they enter the environment. In this review, we summarized the properties of AGNPS, including their size, shape, concentration, agglomeration, and interactions with biological systems. We also discussed how these properties can lead to impaired mitochondria function and ultimately cell death. Finally, we provide an overview of the current research into the toxicity of AGNPS and their potential applications in environmental cleanup. This article was authored by Mamuta Actor, MD to Jeden Sikter, MD Mostafizer Rahman, and others.