 This study investigated the effects of zinc and estradiol on renal ischemia slash reperfusion injury, IRI, and ovariectomized rats. It found that both zinc and estradiol can reduce renal damage caused by IRI, with zinc being more effective than estradiol. Estradiol improved renal function and reduced oxidative stress, while zinc had a greater impact on reducing oxidative stress. This article was authored by Phurobercat, Ardesher Talibai, and Metinemetbax.