Hydrochloric Acid (HCl) Production In The Stomach Animation





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Published on Aug 3, 2010

This is a quick animation of how HCl is produced in the stomach. So this was extra credit for a class and I didn't have much time to go more in detail. I apologize for any errors that the animation might have. I also included what I was saying, because I know some people learn better if they are able to read it.

Hydrochloric Acid Production in the cell
•In order to protect the cells from the damaging acidity of hydrochloric acid, the parietal cell has to produce the components of HCl separately.
•Histamine, Gastrin, and ACh will bind to receptors on the parietal cell. This initiates the HCl production process. All three chemicals have to bind to cell in order for this process to occur, otherwise hydrochloric production won't happen.
•Carbon dioxide diffuses into the cell, and the enzyme carbonic anhydrase catalyzes the reaction between carbon dioxide and water to form carbonic acid.
•Carbonic acid dissociates into bicarbonate ion and hydrogen ion. As the bicarbonate ion accumulates into the cell, bicarbonate ion is ejected through the basal cell membrane into the capillary blood. As a result, blood draining from the stomach is more alkaline than the blood serving it, this is known as the alkaline tide.
•The bicarbonate/chloride antiporter in the plasma membrane exchanges bicarbonate molecules going out for chloride ions coming in. This is known as a chloride shift.
•ATP will bind to the hydrogen/potassium ATPase, where potassium ions are counter transported into the parietal cell in exchange for hydrogen ions. Chloride will simply diffuse thru the cell membrane and enter the gastric gland.
•In the gastric gland, chloride ions will combine with hydrogen ions to form HCl, which will then be secreted into the stomach

Programs used:
-Macromedia Fireworks
-Macromedia Flash
-Prism video converter
-Windows Movie Maker

Narrated by me obviously, I personally don't like how my voice sounds in this video.

And the background music is "So What" by the Mile Davis Sextet

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