 Oral fungal infections are often caused by Candida albicans, and can be associated with other diseases like coronavirus disease, 2019, COVID-19, oral leukoplakia, and oral erythroplakia. Tenacin is a protein found at sites of tissue damage and chronic inflammation, while matrix metalloproteinase-9, MMPK-9, is a zinc dependent enzyme that breaks down extracellular matrix, allowing for tissue invasion metastasis. This review discusses how these two proteins may play a role in the development of fungus-related oral leukoplakia and oral erythroplakia, which are both associated with COVID-19. This article was authored by Sidra Oslam and Sarah Gaffer.