 This research explores the relationship between temporal lobe epilepsy and topopathy. It found that changes in tau phosphorylation dynamics occur at a much earlier time point after status epilepticus than has previously been described. This suggests that seizures promote tau phosphorylation in vivo, but begins much earlier than previously thought. Future work will need to further investigate how these changes develop over longer periods of time. Additionally, it will also need to characterize the effect of topopathy on electrical activity in vivo and in vivo.