 Recognition of antibiotic stewardship programs, ASPS, as essential components of quality health care has dramatically increased in the past decade. ASPS are now required across hospital settings as a condition of participation for the Centers for Medicare and Medicaid Services and for accreditation by the Joint Commission. The urgency of success becomes progressively greater as complex patterns of antibiotic resistance continue to emerge, exacerbated by unpredictable factors such as a worldwide pandemic. This article was authored by Tema F. Barlam.