 This systematic review found that racial ethnic minority groups and those from low socioeconomic status, SES, are at greater risk of contracting COVID-19, being hospitalized due to COVID-19 and dying from COVID-19 compared to their counterparts who belong to other racial ethnic groups or have high SES. Furthermore, this review identified several factors associated with increased risk of COVID-19, including low levels of education, poverty, poor housing conditions, low household income, speaking in a language other than the national language in a country, and living in overcrowded households. These findings suggest that public health policymakers, practitioners, and clinicians should be aware of these inequalities and strive to reduce the gap between vulnerable populations and others by providing resources and support to those who may be at greatest risk. This article was offered by Ahmed Khan Jihani, Chabnam Yazidi, Kamal Gholipur, and others.