 The biocomposite films based on hydroxypropylmethylcellulose, HPMC, reinforced with silver nanoparticles, AGNPs, and titanium dioxide nanoparticles, TO2NPs, were developed. These films exhibited improved physical and mechanical properties such as tensile strength, TS, elongation, E, Young's elastic modulus, EM, water vapor permeability, WVP, and transparency compared to the unreinforced HPMC film. Additionally, the nanocomposite films demonstrated strong antibacterial activities against tested pathogens in the contact surface zone. This article was authored by L.Sate Cater, Adele Barnasoui, Bossma Abu Gabal, and others.