 Propranolol is the most commonly prescribed medication for treating migraine attacks, but its effectiveness can be limited due to poor bioavailability. This study developed a novel thermoresponsive limonene-based microemulsion muco-adhesive nanogel to increase the absorption of propranolol into the bloodstream and improve its therapeutic efficacy. The limonene-based microemulsion nanogel demonstrated excellent muco-adhesive properties and controlled release of propranolol, resulting in improved brain penetration and enhanced therapeutic efficacy. This article was authored by Koth R. K. Abla, Soraya Domiati, Rania El Majub and others.