 This research paper examines the similarities between human and canine osteosarcoma and how they can be used to better understand the disease and its treatment. It found that two genes, interleukin-8, Illinois-8, and solute-carrier family-1, glial-high affinity glutamate transporter, member-3, SLC-1A3, are expressed at higher levels in canine osteosarcoma than in human osteosarcoma. This suggests that these genes may play a role in the development or progression of the disease. Additionally, the researchers found that Illinois-8 and SLC-1A3 protein expression in pediatric osteosarcoma tissue was correlated with poor outcomes, suggesting that these proteins may be involved in the progression of the disease. These findings suggest that studying canine osteosarcoma may provide valuable insights into the disease and its treatment. This article was offered by Trish Timothy, Hewitt-Steven, Pickie-Pierro, and others.