 Wheat oral immunotherapy, OIT, is a promising treatment for food allergy due to its ability to modify abnormal immunologic mechanisms, but may have less efficacy compared to sublingual or epikutaneous immunotherapy methods. Wheat OIT may be considered as an alternative treatment option for those in which wheat avoidance is not sufficient to prevent frequent events of anaphylaxis resulting from inadvertent exposure to small amounts of wheat among this population, although few clinical trials about wheat OIT are available.