 This study demonstrates that flubendazole, FLU, and anthelminthic drug can reduce the expression of PD-1 in immunocompet mice, leading to improved anticancer efficacy. Furthermore, this study suggests that FLU may be able to induce apoptosis in cancer cells by activating the AP-1 transcription factor. This article was authored by Uli, Ben Wu, M.D. Jaka Hossein, and others.