 Abstract retinal ischemia reperfusion, RIR, injury is caused by the overproduction of reactive oxygen species, ROS. Quercetin, K, a naturally occurring flavonoid, has been shown to have strong antioxidant properties. However, its limited bioavailability and poor penetration across ocular barriers limits its effectiveness in treating RIR injuries. To address these issues, researchers developed a novel platform for delivering K to the retina using ROS-responsive mitochondria-targeted liposomes, K at TPPROS lips. This platform was found to be highly effective in reducing RIR injury in both cell culture models and animal studies. It was also found to be safe and well-tolerated by the animals. These results suggest that K at TPPROS lips may provide a promising therapeutic option for treating RIR injuries. This article was authored by Lian Zhao, Long Bing Ling, Jing Lu, and others. We are article.tv, links in the description below.