 The Clinical and Translational Science Award, CTSA, Institutional Development Award program infrastructure for clinical and translational research, idea, and cooperative extension system, CS, have come together to form a partnership to address rural health disparities. A one-day seminar was held to identify common goals and objectives, as well as potential areas of collaboration. The seminar identified several key themes, including defining rural, identifying barriers and challenges, and exploring strategies and opportunities. These themes provide a framework for future collaboration between the three organizations. This article was authored by Michael Esgutta, Latoya J. Anil, Roberta Rapportella, and others.