 NLRP3-inflammosomes are a family of multi-protein complexes that play a key role in the detection and processing of danger-associated molecular patterns, damps, and are responsible for the release of pro-inflammatory cytokines such as IL-1-beta. These complexes can be activated by various environmental and physiologic stimuli, including bacterial or viral infections, endoplasmic reticulum, ER, stress, and oxidative stress. The NLRP3-inflammosome is the most studied and best characterized member of the inflammasome family, and is thought to be the most clinically relevant due to its involvement in numerous inflammatory diseases. Recent evidence suggests that NLRP3-inflammosomes may also be involved in the pathogenesis of metabolic diseases, such as obesity and type 2 diabetes. This article was authored by Amna Abderazek, Tatiana Syrovets, Dominique Couchy, and others. We are article.tv, links in the description below.