 Myself, Dr. Lipsa Bhutani from Department of Radiology, Pramukh Swami Medical College, Karamsad, Gujarat. So my topic for preparation presentation is MRI evaluation of developmental delay in children. So developmental delay is defined as substantial delay in one or more age-appropriated developmental domains. It has an estimated occurrence of 1 to 3% worldwide. MRI is the greatest monality to investigate such patients. Evaluation of a child with developmental delay is important, not only because it allows timely diagnosis and handling, but also useful for parental counselling regarding the result of their child and to detect any possible risk of recurrence in the family members. The degree of developmental delay is further sub-categorized as mild, moderate and severe. If the functional age is less than 33% below the chronological age, then it is called as mild. If the functional age is 34 to 66%, then it is called as moderate. And if the functional age is more than 66% of chronological age, then it is called as severe developmental delay. So my aim is to study the prevalence of normal and abnormal MRI findings in pediatric patients with developmental delay and further classify the abnormal MRI based on the findings and to establish the utility of MRI for the same. So inclusion criteria are pediatric patients with clinically diagnosed developmental delay below the 15-year of age had been referred to my department for brain MRI were included in this study. Materials and methods. This is retrospective analytics study of 54 children with developmental delay referred for MRI at the department of radio diagnosis at Tarshir Keir Hospital, Shri Krishna Hospital, Karam Siddh. Performed on Siemens Spectra 3 Tesla MRI scanner. Non-contrast MRI scan of brain was performed by obtaining 4 mm thick T1 weighted, T2 weighted, diffusion weighted and ADC as well as susceptibility weighted actual images. 5 mm thick flare and T2 coronal images and 4 mm thick T1 weighted sagittal images. Patients were sedated by trained and sociologist in required cases. MRI brain was done and results were categorized into different subgroups according to radiological findings. So there are five groups. First one is perinatal hypoxic insult. It is based on the clinical history and MRI abnormalities. This group includes hypoxic insult in the perinatal period in preterm or term gestational children. Second is structural brain abnormalities. Third is white matter or metabolic disease. Fourth is other findings and fifth is normal MRI. So in development and delay there are 9% cases of ischemic insult, 11% cases are structural abnormality, 35% are white matter disease, 15% other findings and 30% are normal MRI. So this is the few images of the white matter abnormalities. First one is crepe stasis. It is lysosomal disorder in which there is periventricular T2 hyperintensity is noted in osteoporital region. Second one is metachromatic leukodystrophy in which symmetrical hyperintensity is noted in the frontal and periventricular white matter. Third one is allad. Acute leukoencephalopathy with restricted diffusion in which area of restricted diffusion are seen in both grey and white matter. Now fourth is the periventricular leukomalacia. So there is irregular margins of body and trigonoflateral ventricle with ventricular megali and there is also loss of periventricular white matter. Then cortical tubers are seen in tuberous sclerosis. Then there is eye of tiger sign which is seen in PKAN, pentothenate kinase associated neurodegeneration in which symmetrical hyperintensity is noted in clopus pallidus. Now there is corpus callosum egenesis. There is racing car appearance is seen in this. Now holoprosensifeli, there are three types of holoprosensifeli. First one is alobar, semi-lobar and lobar. In semi-lobar there is incomplete forebrain division. So this is the number of cases. Now white matter abnormalities. So one case out of 19 cases, one case is of halate. One for conicterus, one for PKAN, one for tuberous sclerosis, one lake syndrome. Six cases are demyelination, two for PVL. Hemosiderin deposits one and other leukodystrophis five. Now structural abnormalities. In which I found that gliotic areas of bilateral parito-oscipital loop, bilateral parito-oscipital polymicrogyria, smooth thinning of corpus callosum and bilateral colposypheli one case. Then egenesis of corpus callosum one, then prominent verteurobin space in both lentiform nucleus one, semi-lobar holoprosensifeli one, cerebroletrophy one and isometrical thalamus one. Now other abnormalities like cerebral micro hemorrhages, ependymoma of fourth ventricle, extra-dural fluid collection in retro cerebellar region and there is early cerebroletrophy due to bit-well efficiency. Now results. Out of all 54 pediatric patients with developmental delay, 16 patients were found normal and 38 patients were found abnormal along MRI findings, so ratio of 30-70. Out of 38 patients with abnormal MRI findings, 19 patients were so white-meter abnormality, which is most commonly seen. Five patients rose is chronic insult, six patients rose structural abnormalities and eight patients rose other abnormalities. Out of 19 patients with white-meter abnormalities, 11 patients has history of ICU admissions, while out of 16 patients with normal MRI, only six patients has history of ICU admissions. So patients with developmental delay shows wide range of MRI brain findings from completely normal to abnormal. Large number of patients with abnormal MRI brain shows predominantly white-meter abnormalities. Non-contrast MRI scan of brain is very useful modality for the children with developmental delay. However, further sequential MRI may be helpful to ascertain disease progression. Advanced-like functional MRI diffusion tensor imaging and MR spectroscopy provide more information for structurally normal brain of children with developmental delay. So these are my references. Thank you.