 This study investigated the relationship between the topographical skin properties and the underlying collagen and elastic fibers in the dermal layer of the skin in vivo. Two methods were used, skin relief analysis and line field confocal optical coherence tomography, LCOCT, imaging. The former was used to measure the density of the skin lines printed on the skin surface and their orientation, while the latter provided three-dimensional images of the skin volume. The result showed a strong correlation between the skin lines at the surface and the structuring depth of its layers in the volume, 0.40 or spearmen less than 0.73. These findings suggest that the topographical skin properties may be related to the structural organization of the dermal layer of the skin. This article was authored by Ied Marim, Gillerman Ammoury, Abelon Marie-Angeli, and others.