 The only non-toxic, non-caloric, or low-calorie sweetener may be Arithritol. For a while it was only available in Japan, but now it's pretty much available anywhere. It's found naturally in pears and grapes, but industrially we just have yeast make it for us. It doesn't cause cavities and hasn't been implicated in fibromyalgia, preterm birth, headaches, hypertension, brain disorders, platelet disorders. In videos in years past, I've talked about Arithritol as being harmless, but new data suggests I may have to change my tune. Now it actually may be helpful. Adding to its role as a low-calorie, tooth-friendly bulk sweetener, Arithritol may be a sweet antioxidant. This shows the dose-dependent protective effect of an increasing concentration of Arithritol on the oxidative destruction of red blood cells. The reason they even looked for antioxidant activity is because it structurally looks like mannitol, a well-known antioxidant. The problem with mannitol and the other polyols, such as xylitol and sorbitol, is that they aren't absorbed and so can cause gastrointestinal symptoms lowered down in the colon. Safety studies suggest that Arithritol, however, is well-tolerated and shows no signs of toxicity, and is therefore an excellent sugar substitute. For example, for individuals with diabetes, because it can both replace sugar and maybe even help reduce free radical formation, both are expected to reduce the onset and progression of painful and life-threatening diabetic complications.