 This review describes the current state of knowledge on the use of naturally occurring compounds from plants, known as phytochemicals, in cancer therapy. These compounds often act by regulating molecular pathways implicated in cancer growth and progression, such as increasing antioxidant status, carcinogen inactivation, inhibiting proliferation, inducing cell cycle arrest and apoptosis, and regulating the immune system. The authors aim to expand phytochemical research not only for its scientific soundness, but also for its potential drugability, focusing on information about anti-cancer phytochemicals evaluated at preclinical and clinical levels. This article was authored by Amit S. Jodhari, Pula V. C. Mandave, Manasi Deshpande, and others.