 This paper describes the weather, climate, and climate variability in the Andes-Cordillera region of South America using instrumental observations, explaining how the long meridional extent of the Andes and disruption of large-scale circulation by this topographic barrier affect precipitation, temperature, and wind patterns. Additionally, the study examines the impact of the El Nino-Southern Oscillation phenomenon on temperature and precipitation regimes along the Andes. This article was authored by R. D. Garode.