 Hydrogel adhesives have been developed to address the unique challenges associated with treating GI tract injuries. Recent advancements include materials designed for specific environments such as those found in the GI tract and compositions that provide improved mechanical strength and faster dilation times. Despite these improvements, there remains room for improvement in terms of underwater adhesion strength, acid resistance, and overall performance. Future research should focus on developing new materials and compositions that can better address the needs of GI tract wounds. This article was authored by Xinyu Hu and Mark W. Grinstaff.