 Abstract pre-organization is a fundamental design principle used by nature which enables multiple functionalities to be expressed in a synergistic manner. This results in improved performance when compared to random or isolated arrangements as demonstrated by the use of uranium sequestration as a model application. The resulting material has chelating groups populated adjacently in a spatially locked manner, displaying up to two orders of magnitude improvement over a random and isolated manner. Furthermore, this material can reduce uranium concentration from 5 ppm to less than 1 ppb within 10 minutes, even while being exposed to high levels of competing ions. It also has a capacity of 5.01 mg per g for seawater uranium extraction, making it one of the most efficient materials reported to date. This article was authored by Chi Sun, Yen Pei Song, Brianna Aguila, and others.