 This research examined the spatial extent and distribution of water hyacinth in Lake Victoria, Uganda, as well as the determinants of its presence and the effect it had on water quality. It found that the coverage and distribution of water hyacinth varied over space and time, being most prevalent where there was less water surface area and when certain environmental factors such as wind, water level changes and construction activities were present. Additionally, water hyacinth had a negative impact on water quality, decreasing pH, total phosphorus, biological oxygen demand, chemical oxygen demand, turbidity, and transparency. To mitigate the effects of water hyacinth, the authors recommend implementing integrated weed control measures, catchment management plans, and point and non-point pollution source control. This article was authored by Hussein Kiambah, Bernard Baesa, Joy Fredisaba, and others.