Cerebral organoid photos courtesy: M. Stachowiak, Creative Commons; image legend was removed from original Full caption: In cerebral organoids generated from stem cells of patients with schizophrenia, (image on the right), disruption in the layers of stem cell (red) surrounding the brain-like ventricles was evident as early as two weeks into the development of the organoids – roughly comparable to the first trimester of pregnancy. Formation of neurons (green) is clearly impaired compared to the control figure.
Schizophrenia Begins During Pregnancy, New Evidence Suggests https://www.sciencealert.com/schizoph... “A new study has found that schizophrenia could originate as early as the first 12 weeks of pregnancy, which means we might be able to eventually treat it in utero before birth.”
Cerebral organoids reveal early cortical maldevelopment in schizophrenia—computational anatomy and genomics, role of FGFR1 https://www.nature.com/articles/s4139... “Studies of induced pluripotent stem cells (iPSCs) from schizophrenia patients and control individuals revealed that the disorder is programmed at the preneuronal stage, involves a common dysregulated mRNA transcriptome, and identified Integrative Nuclear FGFR1 Signaling a common dysregulated mechanism.”
Schizophrenia originates early in pregnancy, 'mini-brain' research suggests https://medicalxpress.com/news/2017-1... “Symptoms of schizophrenia usually appear in adolescence or young adulthood, but new research reveals that the brain disease likely begins very early in development, toward the end of the first trimester of pregnancy. The finding opens up a new understanding of this devastating disease and the potential for new treatment possibilities in utero.”
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