 In this study, two botanical extracts, pomegranate fruit and grape seed, were evaluated for their effects on bone resorption and formation. Both extracts showed antiresorptive activity, reducing INKL expression in milligram, 63 cells and decreasing calcium loss in osteoporotic rats. Additionally, a combination of pomegranate fruit and grape seed extracts was found to be effective at preventing bone loss in overreacted rats. Furthermore, both extracts were also found to promote bone formation, with quercetin and licorice extracts showing the most potent effect. Overall, these findings suggest that a combination of pomegranate fruit and grape seed extracts may have potential applications for improving bone health.