 Helianthus tuberosis L, Jerusalem artichoke, produces inulin, a type of fructin, which has many biotechnological applications, such as sugar syrup production, prebiotics, and fiber in diabetic foods. This can help reduce blood sugar and cholesterol levels. Drought reduces inulin accumulation in the tubers of Jerusalem artichoke as the plants protect themselves from this stress by inducing stress gene responses, resulting in growth reduction. Endophytic bacteria are promising candidates to promote plant growth and yield, especially under abiotic stress. Three endophytic bacteria with plant growth promoting properties were examined for their ability to improve Jerusalem artichoke growth and yield under both well-watered and drought conditions when inoculated individually or in combinations in pod experiments with a two factorial random, complete block design. The interactions of the endophytic bacteria and plant host determined the differential gene expression in response to drought as revealed by quantitative polymerase chain reaction. A single inoculum of the endophytic bacteria increased the height, weight, root traits. This article was authored by Pacha Bumahom, Junthima Namwangsa, Nimit Voresuit, and others. We are article.tv, links in the description below.