 This systematic review and meta-analysis evaluates the effectiveness, adherence, and other process outcomes of non-clinician guided digital mental health interventions. The results suggest that guided digital mental health interventions are helpful to improve mental health outcomes regardless of the qualifications of the individual performing the intervention and that the presence of a non-clinician guide improves effectiveness outcomes compared to having no guide. Non-clinician guided interventions did not yield significantly different adherence outcomes when compared with unguided interventions, though a general trend of improved adherence was observed within non-clinician guided interventions. Further research should focus on the specific types of tasks these paraprofessionals can successfully provide and their associated outcomes. This article was authored by Calista Leung, Julia Pei, Kristen Hudeck, and others.