 This study investigated the impact of switching from a histidine-rich protein 2, HRP2, only rapid diagnostic test, RDT, to one which uses other markers to detect Plasmodium falciparum. It found that when the false negative rate reaches certain thresholds, it will restore the ability to correctly diagnose symptomatic malaria infections. However, this may not always lead to the extinction of HRP2 negative parasites, as they continue to circulate at low densities. Additionally, if the switch does not occur, then the parasite population becomes fixed and unable to be detected by the RDT. Therefore, long-term strategies should be implemented to ensure accurate diagnoses and surveillance. This article was authored by Alicia Chaudhury, Jane Cunningham, Qin Cheng, and others.