 Retroma is a key component of cellular homeostasis, as it regulates the sorting and transport of integral membrane proteins and controls the maturation of the endolysosomal network. When retroma is dysfunctional, it can lead to neurodegenerative diseases such as Parkinson's and Alzheimer's. To better understand how retroma dysfunction affects cells, researchers used an integrated multiomics approach to study a human glioblastoma cell line. They found that retroma dysfunction leads to widespread changes in the lysosomal proto, increased lysosomal exocytosis, and altered cell surface proteins and secretomes. These findings suggest that retroma plays a critical role in maintaining lysosomal homeostasis and protecting against neurodegeneration.