 Post-acute sequelae of COVID-19, PSC, or long COVID, has caused concern but the burden and risk factors are not well understood. Here, the authors use U.S. electronic health record data and estimate an overall burden of PSC of 7% at 6 months, with variation by severity of acute infection, baseline health status and demographics. This article was authored by Yang Xie, Benjamin Thao, and see it all early.