 the intestine's ability to regulate what enters and exits its lining is essential for maintaining good health. This process is known as intestinal barrier function which is controlled by tight junction proteins and various signaling pathways. When this system is disrupted due to genetic mutations, gut microbes, autoimmunity, diet, or other factors, it can lead to diseases such as inflammatory bowel disease, IBD, obesity, and more. Restoring barrier function through medication or probiotics may be beneficial in treating these diseases.