 Estimate guests, dear colleagues, and friends. Patient harm due to unsafe care is a leading cause of deaths and disability worldwide. It's a problem for all countries, but it's particularly acute in resource-constrained settings. Safety lapses cause 2.6 million deaths each year in hospitals in low- and middle-income countries alone. It's estimated that more than half of these cases of patient harm are preventable. Improving patient safety is essential to health system resilience and sustainability, and to achieving universal health coverage. The WHO Global Patient Safety Action Plan 2021-2030 provides a roadmap for governments to prioritize and integrate patient safety into their national health plans. The Action Plan is supported by WHO's Global Patient Safety Challenges, which advocate for systemic improvements on critical themes such as infection prevention and control, safe surgery, and medication safety. And the upcoming Global Patient Safety Report 2023 will take stock of what has been achieved in the last two years. WHO is proud to partner with the Patient Safety Movement Foundation to build a culture of safety in health systems across the world. I wish you all a productive summit. I thank you.