 Mechanical cues from microenvironments are transmitted to the nucleus via physical connections between the cytoskeletons. These connections affect the transcriptional activity of the nucleus which can be regulated by the actomycin and microtubules. Actomycin generates intracellular traction forces while microtubules are responsible for negative regulation of nuclear invagination and positive regulation of nuclear wrinkling. Chromatin remodeling is mediated by these nuclear shape changes which ultimately lead to cell gene expression and phenotype determination. Disrupting the actomycin or microtubule results in chromatin accessibility loss which can be partially restored by microtubule interference through nuclear shape control. This article was authored by Chiwen Gang, Xifeng Khan, Qian Sun, and others.