 Adipose tissues play an important role in regulating systemic energy balance, glucose homeostasis, immune responses, reproduction, and longevity. They also have the ability to expand and contract depending on the body's need for energy storage. When overexpanded, adipose tissue can be a major contributor to obesity and its associated metabolic disorders such as diabetes. Recent research has identified precursor cells that give rise to adipose tissue and these cells are influenced by both intrinsic and extrinsic factors. Understanding the mechanisms behind the development and maintenance of adipose tissue will help us develop new treatments for obesity and its related metabolic disorders. This article was authored by Jiayin Yi, Chen Jiayou, Yong Liang, and others.