 this study examined the impact of sex chromosome aneuploidy on the transcriptome and methylome in blood, fat, and muscle tissue. The results suggest that X chromosome number has a significant effect on the expression of genes in each tissue, as well as the methylation patterns of those genes. Additionally, the study found that certain genes are differentially expressed or methylated depending on the sex chromosome aneuploidy. This suggests that there may be a unique role for the Y chromosome in regulating the expression of X chromosome genes. This article was authored by MetaVuef and Scacobag, Emma B. Johansson, and others.