 Bacterial cellulose, BC, is a type of cellulose produced by certain types of bacteria when grown under optimal conditions. It is composed of a three-dimensional network of pure cellulose nanofibers and has been used in various industries due to its unique mechanical properties, conformability, and porosity. BC nanocomposites are made up of BC combined with other materials, such as polymers, metals, ceramics, and biomaterials. They can be fabricated using static or agitated cultures, and the resulting material retains the original matte structure from the synthesis process. Biocompatibility testing is important for developing BC-based materials for use in bone, skin, and cardiovascular tissue engineering. This article was authored by Omar Petronkoso, Solene Kamos, and Fernando G. Torres.