 Acidovorax orizy, AO, a bacterium responsible for causing bacterial brown stripe, BBS, in rice crops, can be effectively controlled through the use of natural materials such as chamomile flour extract. This study has successfully developed two types of nanoparticles, hemagnesium oxide, milligram O, and manganese oxide, MNO2, which have been shown to reduce the growth of AO strain RS2 by up to 71%. Additionally, these nanoparticles have also been found to disrupt the cell membranes of the bacteria, resulting in the release of cytoplasm and ultimately leading to cell death. Furthermore, the nanoparticles have been observed to induce apoptosis in the bacteria, thereby reducing its ability to form biofilms and move freely. Overall, this study suggests that the use of milligram O and MNO2 nanoparticles may provide a viable solution for controlling BBS in rice crops. This article was authored by Celebomio Leitanogonimi, Frame Jong, Yasmin Abdullah, and others.