 The study investigates the effects of 36 naturally occurring flavonoids and related compounds on NO production in activated macrophages, finding that eight active compounds inhibit INOS protein and mRNA expression and NO production by inhibiting NFB and STAT-1 activation. The results partially explain the pharmacological efficacy of flavonoids as anti-inflammatory compounds. This article was authored by Marie Hamelainin, Winana Minin, Pia Vuella, and others.