 This study proposes a new method for detecting prostate cancer in the PSA gray zone using a MOS-2-mz hetero structure. The MOS-2-mz hetero structure was found to be more effective than other methods at detecting metabolites in urine samples, resulting in an AUC of 0.959 compared to 0.902 for serum samples. This suggests that the MOS-2-mz hetero structure could be used to accurately diagnose prostate cancer in the PSA gray zone. This article was authored by Xiaowei Xia, Xiaochun Fei, Jiayi Wang, and others.