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Published on Sep 14, 2012
For more info, visit http://www.bio-rad.com/yt/2/proteonxpr36 A prominent challenge to overcome in the field of combinatorial protein engineering is functional screening of identified candidate molecules. The ability to achieve a full kinetic characterization during screening yields valuable insights. In this webinar, the presenters present their experience and methodology in characterizing bispecific affinity molecules. The binding molecules are derived from a combinatorial protein library based on a single albumin-binding domain selected to specifically bind a cancer-related receptor protein. In addition, a demanding competition assay is presented where selected binding proteins compete with the extracellular domain of the receptor for binding to an immobilized natural ligand.